Manchester United have dropped only two points at home all season while Everton have won their last two on the road.
Manchester United Team News
United boss Sir Alex Ferguson will check the fitness of leading scorer Dimitar Berbatov before deciding whether to include the Bulgarian in his plans.
Berbatov missed Tuesday's goalless draw at Newcastle with a minor groin strain and with the Champions League semi-final first leg clash with Schalke looming, with Ferguson will not want to take any chances even though United are looking to avoid failing to score in three successive games for the first time since 2007.
Paul Scholes serves the second game of a three-match ban and Darren Fletcher (virus) is still out but full-back Rafael (hamstring) returns.
Key pair Mikel Arteta and Tim Cahill could return. Arteta has missed four games with a hamstring injury while Cahill has been troubled by a foot problem for the past month.
Midfielder John Heitinga is doubtful after hobbling out of last week's win over Blackburn with a hamstring injury.
Jack Rodwell and Seamus Coleman are both pushing to start after substitute appearances last week but Louis Saha and Marouane Fellaini are long-term absentees.
Manchester United: Van der Sar, Kuszczak, Rafael, O'Shea, Brown, Ferdinand, Smalling, Vidic, Evans, Evra, Fabio, Valencia, Gibson, Anderson, Park, Carrick, Giggs, Nani, Rooney, Berbatov, Hernandez, Owen.
Everton: Howard, Hibbert, Jagielka, Distin, Baines, Coleman, Osman, Rodwell, Neville, Bilyaletdinov, Beckford, Arteta, Cahill, Gueye, Anichebe, Mustafi, Baxter, Vellios, Forshaw, McAleny, Nsiala, Mucha.
Mikel Arteta's injury-time goal secured a 3-3 draw for Everton against Manchester United in September
When Manchester United conceded two stoppage time goals at Goodison Park in September - the second successive away game in which they had thrown away three points in the dying seconds - it appeared as though their bid to regain the Premier League title may have been over before it had really begun. The 3-3 draw when Chelsea were looking down from the summit, dismantling each team that dared step out in front of them with consumate ease.